tert-Butyl piperazine-1-carboxylate → HCID 69497946, compound

HRID 7989Notes

Reaction equation

HRID 7989 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11](C2C(=O)N(CC(C)C)N=C(C3C=CC(C)=C(F)C=3)C=2C)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[Cl:34][C:35]1[CH:64]=[CH:63][C:38]([CH:39]=[CH:40][CH2:41][N:42]2[C:47](=[O:48])[C:46](COS(C)(=O)=O)=[CH:45][C:44]([C:55]3[CH:60]=[CH:59][C:58]([F:61])=[C:57]([CH3:62])[CH:56]=3)=[N:43]2)=[CH:37][CH:36]=1.N1(C(OC(C)(C)C)=O)CCNC[CH2:66]1>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:46]2[C:47](=[O:48])[N:42]([CH2:41][CH:40]=[CH:39][C:38]3[CH:37]=[CH:36][C:35]([Cl:34])=[CH:64][CH:63]=3)[N:43]=[C:44]([C:55]3[CH:60]=[CH:59][C:58]([F:61])=[C:57]([CH3:62])[CH:56]=3)[C:45]=2[CH3:66])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 3

HCID 143452tert-Butyl piperazine-1-carboxylateHCID 672140994-(4-tert-butoxycarbonyl-1-piperazinyl)-methyl-6-(3-fluoro-4-methylphenyl)-2-isobutyl-2H-pyridazin-3-oneHCID 738582892-(4-chlorocinnamyl)-6-(4-fluoro-3-methylphenyl)-4-methanesulfonyloxymethyl-2H-pyridazin-3-one

Product 1

HCID 69497946HCID 69497946, compoundYield 87.9%

Procedure

Following the procedure of Example 1 (10), 2-(4-chlorocinnamyl)-6-(4-fluoro-3-methylphenyl)-4-methane-sulfonyloxymethyl-2H-pyridazin-3-one and tert-butyl 1-piperazinecarboxylate were reacted to yield the title compound as a yellow oil (yield: 87.9%).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-6b78883984ef40e189d6eb0eb0ecab88
Source dataset
uspto-grants-2006_08
Patent number
US07087606B2

Reaction notes

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