2-isobutyl-6-(2,4-difluorophenyl)-4-phthalimidomethyl-2H-pyridazin-3-one → 4-hydroxymethyl-2-isobutyl-6-[4-(methylthio)phenyl]-2H-pyridazin-3-one

HRID 7994Notes

Reaction equation

HRID 7994 reaction equation
FC1C=C(F)C=CC=1C1C=C(CN2C(=O)C3=CC=CC=C3C2=O)C(=O)N(CC(C)C)N=1.[C:32]([C:35]1[C:36](=[O:53])[N:37]([CH2:49][CH:50]([CH3:52])[CH3:51])[N:38]=[C:39]([C:41]2[CH:46]=[CH:45][C:44]([S:47][CH3:48])=[CH:43][CH:42]=2)[CH:40]=1)(O)=[O:33]>>[OH:33][CH2:32][C:35]1[C:36](=[O:53])[N:37]([CH2:49][CH:50]([CH3:51])[CH3:52])[N:38]=[C:39]([C:41]2[CH:46]=[CH:45][C:44]([S:47][CH3:48])=[CH:43][CH:42]=2)[CH:40]=1

Participants

3

Reactant 2

HCID 219915872-isobutyl-6-(2,4-difluorophenyl)-4-phthalimidomethyl-2H-pyridazin-3-oneHCID 219916394-carboxy-2-isobutyl-6-[4-(methylthio)phenyl)-2H-pyridazin-3-one

Product 1

HCID 219916504-hydroxymethyl-2-isobutyl-6-[4-(methylthio)phenyl]-2H-pyridazin-3-oneYield 35.3%

Procedure

Following the procedure of Example 1 (8), 4-carboxy-2-isobutyl-6-[4-(methylthio)phenyl]-2H-pyridazin-3-one was reacted to yield the title compound as a yellow oil (yield: 35.3%).

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-4890823ff7fb4745a8939acecea10f65
Source dataset
uspto-grants-2006_08
Patent number
US07087606B2

Reaction notes

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