Trifluoro-methanesulfonic acid 8-trifluoromethanesulfonyloxy-6H-dibenzo[c,h]chromen-2-Y1 ester → HCID 59610797, compound

HRID 79947Notes

Reaction equation

HRID 79947 reaction equation
C[O:2]C(=O)NC(C(N1CCCC1C1NC(C2C=CC3C4C(=C5C=CC(C6NC(C7CCCN7C(=O)C(NC(OC)=O)C(C)C)=NC=6)=CC5=CC=4)OCC=3C=2)=CN=1)=O)C(C)C.[F:61][C:62]([F:94])([F:93])[S:63]([O:66][C:67]1C=C[C:70]2[C:71]([CH:92]=1)=[CH:72]C=[C:74]1[C:79]=2[O:78][CH2:77][C:76]2[CH:80]=[C:81]([O:84][S:85]([C:88]([F:91])([F:90])[F:89])(=[O:87])=[O:86])[CH:82]=[CH:83][C:75]1=2)(=[O:65])=[O:64]>>[F:94][C:62]([F:93])([F:61])[S:63]([O:66][C:67]1[CH:74]=[C:79]2[O:78][CH2:77][C:76]3[C:75]4[C:70]2=[C:71]([CH2:72][O:2][C:83]=4[CH:82]=[C:81]([O:84][S:85]([C:88]([F:90])([F:91])[F:89])(=[O:86])=[O:87])[CH:80]=3)[CH:92]=1)(=[O:65])=[O:64]

Participants

3

Reactant 2

HCID 59610915Trifluoro-methanesulfonic acid 8-trifluoromethanesulfonyloxy-6H-dibenzo[c,h]chromen-2-Y1 esterHCID 66621320(1-{2-[5-(2-{2-[1-(2-Methoxycarbonylamino-3-methyl-butyryl)-pyrrolidin-2-yl]-3H-imidazol-4-yl}-6-H-dibenzo[c,h]chromen-8-yl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester

Product 1

HCID 59610797HCID 59610797, compound

Procedure

(1-{2-{[5-(7-{2-[1-(2-Methoxycarbonylamino-3-methyl-butyryl)-pyrrolidin-2-yl]-3H-imidazol-4-yl}-5,10-dihydro-chromeno [5,4,3-cde]chromen-2-yl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester: Title compound was prepared according to the method employed to prepare (1-{2-[5-(2-{2-[1-(2-Methoxycarbonylamino-3-methyl-butyryl)-pyrrolidin-2-yl]-3H-imidazol-4-yl}-6-H-dibenzo[c,h]chromen-8-yl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester, substituting trifluoro-methanesulfonic acid 7-trifluoromethane sulfonyloxy-5,10-dihydro-chromeno[5,4,3-cde]chromen-2-yl ester for trifluoro-methanesulfonic acid 2-trifluoromethanesulfonyloxy-6-H-dibenzo[c,h]chromen-8-yl ester.

Sources & evidence

ORD record
ord-2f90d6e55f1942a5a77a686a1b243d96
Source dataset
uspto-grants-2014_09
Patent number
US08841278B2

Reaction notes

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