Morpholine → 2-N-(5-cyclopropyl-1H-pyrazol-3-yl)-3-fluoro-6-N-[1-(4-fluorophenyl)ethyl]-5-(morpholin-4-ylmethyl)pyridine-2,6-diamine

HRID 799499Notes

Reaction equation

HRID 799499 reaction equation
[CH2:29]1[CH2:30][O:31][CH2:32][CH2:33][NH:34]1.[CH:1]1([c:4]2[cH:5][c:6]([NH:9][c:10]3[n:11][c:12]([NH:19][CH:20]([CH3:21])[c:22]4[cH:23][cH:24][c:25]([F:28])[cH:26][cH:27]4)[c:13]([CH:14]=[O:15])[cH:16][c:17]3[F:18])[n:7][nH:8]2)[CH2:2][CH2:3]1>>[CH:1]1([c:4]2[cH:5][c:6]([NH:9][c:10]3[n:11][c:12]([NH:19][CH:20]([CH3:21])[c:22]4[cH:23][cH:24][c:25]([F:28])[cH:26][cH:27]4)[c:13]([CH2:14][N:34]4[CH2:29][CH2:30][O:31][CH2:32][CH2:33]4)[cH:16][c:17]3[F:18])[n:7][nH:8]2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 874072396-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-5-fluoro-2-[1-(4-fluorophenyl)ethylamino]pyridine-3-carbaldehyde

Product 1

HCID 777018292-N-(5-cyclopropyl-1H-pyrazol-3-yl)-3-fluoro-6-N-[1-(4-fluorophenyl)ethyl]-5-(morpholin-4-ylmethyl)pyridine-2,6-diamine

Sources & evidence

ORD record
ord-2dae90b908434515ae21ff0eb6ba2d8d
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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