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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 79965Generated: October 28, 2026

2-Isopropyl-3,6-dimethoxy-5-[2-(2,2,2-trifluoro-ethoxy)-ethyl]-2,5-dihydropyrazine → 2-Methoxycarbonylamino-4-(2,2,2-trifluoro-ethoxy)-butyric acid methyl ester

https://huagongshe.com/reaction/79965

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Isopropyl-3,6-dimethoxy-5-[2-(2,2,2-trifluoro-ethoxy)-ethyl]-2,5-dihydropyrazineHCID 66620460—
Reactant5,5,5-Trifluoro-2-methoxycarbonylamino-pentanoic acid methyl esterHCID 72337883—
Product2-Methoxycarbonylamino-4-(2,2,2-trifluoro-ethoxy)-butyric acid methyl esterHCID 72338020—

Reaction Steps

This compound was made by the same procedure as 5,5,5-Trifluoro-2-methoxycarbonylamino-pentanoic acid methyl ester, using 2-Isopropyl-3,6-dimethoxy-5-[2-(2,2,2-trifluoro-ethoxy)-ethyl]-2,5-dihydropyrazine as the starting material. 1H-NMR: 400 MHz, (CDCl3) δ: 5.51-5.43 (br, 1H), 4.51-4.43 (m, 1H), 3.83-3.63 (m, 10H), 2.22-2.13 (m, 1H), 2.13-2.03 (m, 1H) ppm.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08841278B2
Source datasetuspto-grants-2014_09
ORD IDord-05a61e19bfd14566a1b09c363a900788
Source noteuspto-grants-2014_09