2-Bromo-5-((tert-butoxycarbonyl)amino)thiazole-4-carboxylic acid → tert-butyl N-[2-bromo-4-[[1-(2,2-difluoroethyl)-5-[4-[methyl-(2,2,2-trifluoroacetyl)amino]azepan-1-yl]pyrazol-4-yl]carbamoyl]-1,3-thiazol-5-yl]carbamate

HRID 799683Notes

Reaction equation

HRID 799683 reaction equation
[Br:26][c:27]1[s:28][c:29]([NH:35][C:36](=[O:37])[O:38][C:39]([CH3:40])([CH3:41])[CH3:42])[c:30]([C:32](=[O:33])[OH:34])[n:31]1.[NH2:1][c:2]1[cH:3][n:4][n:5]([CH2:22][CH:23]([F:24])[F:25])[c:6]1[N:7]1[CH2:8][CH2:9][CH:10]([N:14]([C:15]([C:16]([F:17])([F:18])[F:19])=[O:20])[CH3:21])[CH2:11][CH2:12][CH2:13]1>>[NH:1]([c:2]1[cH:3][n:4][n:5]([CH2:22][CH:23]([F:24])[F:25])[c:6]1[N:7]1[CH2:8][CH2:9][CH:10]([N:14]([C:15]([C:16]([F:17])([F:18])[F:19])=[O:20])[CH3:21])[CH2:11][CH2:12][CH2:13]1)[C:32]([c:30]1[c:29]([NH:35][C:36](=[O:37])[O:38][C:39]([CH3:40])([CH3:41])[CH3:42])[s:28][c:27]([Br:26])[n:31]1)=[O:33]

Participants

3

Reactant 2

HCID 581821562-Bromo-5-((tert-butoxycarbonyl)amino)thiazole-4-carboxylic acidHCID 89456718N-[1-[4-amino-2-(2,2-difluoroethyl)pyrazol-3-yl]azepan-4-yl]-2,2,2-trifluoro-N-methylacetamide

Product 1

HCID 89456793tert-butyl N-[2-bromo-4-[[1-(2,2-difluoroethyl)-5-[4-[methyl-(2,2,2-trifluoroacetyl)amino]azepan-1-yl]pyrazol-4-yl]carbamoyl]-1,3-thiazol-5-yl]carbamate

Sources & evidence

ORD record
ord-215a1993f2fe40d9bd845ace1adbbfaa
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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