5-Chloromethyl-4-(2-methoxy-ethyl)-6-methyl-2-(4-trifluoromethyl-phenyl)-pyrimidine → 2-(3-{[4-(2-Methoxy-ethyl)-6-methyl-2-(4-trifluoromethyl-phenyl)-pyrimidin-5-ylmethyl]-methyl-carbamoyl}-phenoxy)-2-methyl-propionic acid ethyl ester
Reaction equation
[CH2:1]([CH3:2])[O:3][C:4]([C:5]([CH3:6])([O:7][c:8]1[cH:9][c:10]([C:14]([NH:15][CH3:16])=[O:17])[cH:11][cH:12][cH:13]1)[CH3:18])=[O:19].[Cl:20][CH2:21][c:22]1[c:23]([CH2:39][CH2:40][O:41][CH3:42])[n:24][c:25](-[c:29]2[cH:30][cH:31][c:32]([C:35]([F:36])([F:37])[F:38])[cH:33][cH:34]2)[n:26][c:27]1[CH3:28]>>[CH2:1]([CH3:2])[O:3][C:4]([C:5]([CH3:6])([O:7][c:8]1[cH:9][c:10]([C:14]([N:15]([CH3:16])[CH2:21][c:22]2[c:23]([CH2:39][CH2:40][O:41][CH3:42])[n:24][c:25](-[c:29]3[cH:30][cH:31][c:32]([C:35]([F:36])([F:37])[F:38])[cH:33][cH:34]3)[n:26][c:27]2[CH3:28])=[O:17])[cH:11][cH:12][cH:13]1)[CH3:18])=[O:19]Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-0b4ba2c02b434cb785ad0664dcc5c6f8
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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