反应详情

1-(2-Chloro-ethyl)-3-pyridin-3-yl-urea (I-1a: 1000 mg, 5.0 mmol) in dry DMF (10 mL) was added to a stirred solution of sodium hydride (216 mg, 9.0 mmol) in THF (10 mL) at 0° C. The reaction temperature was maintained at room temperature for 30 minutes. The reaction was monitored by TLC (100% ethyl acetate). The reaction mixture was quenched with MeOH (5 mL) at 0° C. The reaction mixture was concentrated under reduced pressure and partitioned between ice water and chloroform. The organic layer was dried over Na2SO4, and concentrated under reduced pressure to afford 800 mg (97% yield) of 1-pyridin-3-yl-imidazolidin-2-one.

1. customThe reaction mixture was quenched with MeOH (5 mL) at 0° C
2. concentrationThe reaction mixture was concentrated under reduced pressure
3. custompartitioned between ice water and chloroform
4. dry with materialThe organic layer was dried over Na2SO4
5. concentrationconcentrated under reduced pressure