6-(2,4-difluorophenyl)-2-isobutyl-4-methanesulfonyloxym ethyl-2H-pyridazin-3-one → 4-carboxy-2-cyclopentylmethyl-6-(3-fluoro-4-methoxyphenyl)-2H-pyridazin-3-one

HRID 8003Notes

Reaction equation

HRID 8003 reaction equation
FC1C=C(F)C=CC=1C1C=C(COS(C)(=O)=O)C(=O)N(CC(C)C)N=1.[CH:26]1([CH2:31][N:32]2[C:37](=[O:38])[C:36]([C:39]([O:41]C)=[O:40])=[CH:35][C:34]([C:43]3[CH:48]=[CH:47][C:46]([O:49][CH3:50])=[C:45]([F:51])[CH:44]=3)=[N:33]2)[CH2:30][CH2:29][CH2:28][CH2:27]1>>[C:39]([C:36]1[C:37](=[O:38])[N:32]([CH2:31][CH:26]2[CH2:30][CH2:29][CH2:28][CH2:27]2)[N:33]=[C:34]([C:43]2[CH:48]=[CH:47][C:46]([O:49][CH3:50])=[C:45]([F:51])[CH:44]=2)[CH:35]=1)([OH:41])=[O:40]

Participants

3

Reactant 2

HCID 219914166-(2,4-difluorophenyl)-2-isobutyl-4-methanesulfonyloxym ethyl-2H-pyridazin-3-oneHCID 219916512-cyclopentylmethyl-6-(3-fluoro-4-methoxyphenyl)-4-methoxycarbonyl-2H-pyridazin-3-one

Product 1

HCID 219916014-carboxy-2-cyclopentylmethyl-6-(3-fluoro-4-methoxyphenyl)-2H-pyridazin-3-oneYield 71.1%

Procedure

Following the procedure of Example 1 (7), 2-cyclopentylmethyl-6-(3-fluoro-4-methoxyphenyl)-4-methoxycarbonyl-2H-pyridazin-3-one was reacted to yield the title compound as a yellow powder (yield: 71.1%).

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-3797b85c4944485da49699fb9a982709
Source dataset
uspto-grants-2006_08
Patent number
US07087606B2

Reaction notes

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