2-isobutyl-6-(2,4-difluorophenyl)-4-phthalimidomethyl-2H-pyridazin-3-one → 2-cyclopentylmethyl-6-(3-fluoro-4-methoxyphenyl)-4-hydroxymethyl-2H-pyridazin-3-one

HRID 8004ノート

反応式

HRID 8004 の反応式
FC1C=C(F)C=CC=1C1C=C(CN2C(=O)C3=CC=CC=C3C2=O)C(=O)N(CC(C)C)N=1.[C:32]([C:35]1[C:36](=[O:56])[N:37]([CH2:50][CH:51]2[CH2:55][CH2:54][CH2:53][CH2:52]2)[N:38]=[C:39]([C:41]2[CH:46]=[CH:45][C:44]([O:47][CH3:48])=[C:43]([F:49])[CH:42]=2)[CH:40]=1)(O)=[O:33]>>[CH:51]1([CH2:50][N:37]2[C:36](=[O:56])[C:35]([CH2:32][OH:33])=[CH:40][C:39]([C:41]3[CH:46]=[CH:45][C:44]([O:47][CH3:48])=[C:43]([F:49])[CH:42]=3)=[N:38]2)[CH2:55][CH2:54][CH2:53][CH2:52]1

参加物

3

反応物 2

HCID 219915872-isobutyl-6-(2,4-difluorophenyl)-4-phthalimidomethyl-2H-pyridazin-3-oneHCID 219916014-carboxy-2-cyclopentylmethyl-6-(3-fluoro-4-methoxyphenyl)-2H-pyridazin-3-one

生成物 1

HCID 219916522-cyclopentylmethyl-6-(3-fluoro-4-methoxyphenyl)-4-hydroxymethyl-2H-pyridazin-3-one収率 47.3%

実験手順

Following the procedure of Example 1 (8), 4-carboxy-2-cyclopentylmethyl-6-(3-fluoro-4-methoxyphenyl)-2H-pyridazin-3-one was reacted to yield the title compound as a yellow powder (yield: 47.3%).

後処理

  1. customwas reacted

出典と根拠

ORDレコード
ord-740a126536784c0ba93e047e84719970
出典データセット
uspto-grants-2006_08
特許番号
US07087606B2

反応ノート

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