Dichloromethane → 3-Chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)-4-oxo-1,4,5,6-tetrahydropyridine-2-carboxylic acid methyl ester

HRID 800423Notes

Reaction equation

HRID 800423 reaction equation
[CH3:1][O:2][C:3](=[O:4])[C:5]1=[CH:10][C:9](=[O:11])[CH2:8][CH:7]([c:12]2[c:13]([F:21])[c:14]([O:19][CH3:20])[c:15]([Cl:18])[cH:16][cH:17]2)[NH:6]1.[Cl:27][CH2:28][Cl:29].[S:22]([Cl:23])(=[O:24])([Cl:25])=[O:26]>>[CH3:1][O:2][C:3](=[O:4])[C:5]1=[C:10]([Cl:25])[C:9](=[O:11])[CH2:8][CH:7]([c:12]2[c:13]([F:21])[c:14]([O:19][CH3:20])[c:15]([Cl:18])[cH:16][cH:17]2)[NH:6]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 24648Sulfuryl chlorideHCID 596121066-(4-Chloro-2-fluoro-3-methoxyphenyl)-4-oxo-1,4,5,6-tetrahydropyridine-2-carboxylic acid methyl ester

Product 1

HCID 596121323-Chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)-4-oxo-1,4,5,6-tetrahydropyridine-2-carboxylic acid methyl ester

Sources & evidence

ORD record
ord-e86b8a2fbcb5443bbd09a74bf1aaad10
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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