Ethanol → 1-Acetyl-2,3-dihydro-5-[2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-1H-indole-7-carbonitrile

HRID 800499Notes

Reaction equation

HRID 800499 reaction equation
[Br:19][CH2:20][CH2:21][O:22][c:23]1[c:24]([O:29][CH2:30][C:31]([F:32])([F:33])[F:34])[cH:25][cH:26][cH:27][cH:28]1.[C:1]([CH3:2])(=[O:3])[N:4]1[CH2:5][CH2:6][c:7]2[cH:8][c:9]([CH2:15][CH:16]([CH3:17])[NH2:18])[cH:10][c:11]([C:13]#[N:14])[c:12]21.[C:35](=[O:36])([OH:37])[O-:38].[CH3:40][CH2:41][OH:42].[Na+:39]>>[C:1]([CH3:2])(=[O:3])[N:4]1[CH2:5][CH2:6][c:7]2[cH:8][c:9]([CH2:15][CH:16]([CH3:17])[NH:18][CH2:20][CH2:21][O:22][c:23]3[c:24]([O:29][CH2:30][C:31]([F:32])([F:33])[F:34])[cH:25][cH:26][cH:27][cH:28]3)[cH:10][c:11]([C:13]#[N:14])[c:12]21

Participants

6

Reactant 5

HCID 702EthanolHCID 769Bicarbonate IonHCID 923Sodium ionHCID 200943331-Acetyl-5-(2-aminopropyl)-2,3-dihydro-1H-indole-7-carbonitrileHCID 200943351-(2-Bromoethoxy)-2-(2,2,2-trifluoroethoxy)benzene

Product 1

HCID 200943401-Acetyl-2,3-dihydro-5-[2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-1H-indole-7-carbonitrile

Sources & evidence

ORD record
ord-ba2b527de5f8456f8cc261f966545119
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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