3-(5-chloro-4-fluoro-2-hydroxyphenyl)-3-(hydroxymethyl)-1-pentyl-1,3-dihydro-2H-indol-2-one → 5-chloro-6-fluoro-1'-pentylspiro[1-benzofuran-3,3'-indol]-2'(1'H)-one

HRID 800711Notes

Reaction equation

HRID 800711 reaction equation
[CH:27]1([CH2:28][CH2:29][N:30]2[c:31]3[c:32]([cH:33][cH:34][cH:35][cH:36]3)[C:37]([c:38]3[c:39]([OH:40])[cH:41][c:42]4[c:46]([cH:47]3)[O:45][CH2:44][O:43]4)([CH2:48][OH:49])[C:50]2=[O:51])[CH2:52][CH2:53]1.[Cl:1][c:2]1[c:3]([F:26])[cH:4][c:5]([OH:25])[c:6]([C:8]2([CH2:23][OH:24])[C:9](=[O:22])[N:10]([CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])[c:11]3[cH:12][cH:13][cH:14][cH:15][c:16]32)[cH:7]1>>[Cl:1][c:2]1[c:3]([F:26])[cH:4][c:5]2[c:6]([cH:7]1)[C:8]1([C:9](=[O:22])[N:10]([CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])[c:11]3[cH:12][cH:13][cH:14][cH:15][c:16]31)[CH2:23][O:25]2

Participants

3

Reactant 2

HCID 588725173-(5-chloro-4-fluoro-2-hydroxyphenyl)-3-(hydroxymethyl)-1-pentyl-1,3-dihydro-2H-indol-2-oneHCID 666425671-(2-cyclopropylethyl)-3-(6-hydroxy-1,3-benzodioxol-5-yl)-3-(hydroxymethyl)-1,3-dihydro-2H-indol-2-one

Product 1

HCID 592634795-chloro-6-fluoro-1'-pentylspiro[1-benzofuran-3,3'-indol]-2'(1'H)-one

Sources & evidence

ORD record
ord-d2a5fac3dd1f49ab8d7d9bda39979fe1
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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