1-Propanol, 3-amino-2,2-dimethyl- → 3-{4-[2-(2,4-Difluorophenyl)-8-methylimidazo[1,2-a]pyrazin-3-yl]-pyrimidin-2-ylamino}-2,2-dimethylpropan-1-ol

HRID 801025Notes

Reaction equation

HRID 801025 reaction equation
[F:1][c:2]1[c:3](-[c:9]2[n:10][c:11]3[n:12]([cH:13][cH:14][n:15][c:16]3[CH3:17])[c:18]2-[c:19]2[n:20][c:21]([S:25]([CH3:26])(=[O:27])=[O:28])[n:22][cH:23][cH:24]2)[cH:4][cH:5][c:6]([F:8])[cH:7]1.[NH2:29][CH2:30][C:31]([CH2:32][OH:33])([CH3:34])[CH3:35]>>[F:1][c:2]1[c:3](-[c:9]2[n:10][c:11]3[n:12]([cH:13][cH:14][n:15][c:16]3[CH3:17])[c:18]2-[c:19]2[n:20][c:21]([NH:29][CH2:30][C:31]([CH2:32][OH:33])([CH3:34])[CH3:35])[n:22][cH:23][cH:24]2)[cH:4][cH:5][c:6]([F:8])[cH:7]1

Participants

3

Reactant 2

HCID 1173261-Propanol, 3-amino-2,2-dimethyl-HCID 574387742-(2,4-Difluorophenyl)-3-(2-methanesulfonylpyrimidin-4-yl)-8-methylimidazo[1,2-a]pyrazine

Product 1

HCID 160504503-{4-[2-(2,4-Difluorophenyl)-8-methylimidazo[1,2-a]pyrazin-3-yl]-pyrimidin-2-ylamino}-2,2-dimethylpropan-1-ol

Sources & evidence

ORD record
ord-1d127bf8146b4646a55f6f38cf89600b
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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