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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 801213Generated: November 1, 2026

Chloride → (5SR,6RS)-8-benzyl-6-hydroxy-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one

https://huagongshe.com/reaction/801213

Reaction equation

Participants

RoleNameHCIDCharge
ReactantChlorideHCID 312—
ReactantTolueneHCID 1140—
Reactant4-(Trifluoromethoxy)anilineHCID 600848—
ReactantDimethylalumanyliumHCID 16685399—
Reactant1-Benzyl-3-hydroxy-4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl esterHCID 58056619—
Product(5SR,6RS)-8-benzyl-6-hydroxy-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-oneHCID 56602659—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTest data from https://doi.org/10.1039/C8SC04228D
ORD IDord-66e8e5cdd9ef45b4b78e7eb94753befe
Source noteTest data from https://doi.org/10.1039/C8SC04228D