Dimethylamine → 4-dimethylaminomethyl-2-(4-fluorobenzyl)-6-(3-fluoro-4-methoxyphenyl)-2H-pyridazin-3-one

HRID 8013Notes

Reaction equation

HRID 8013 reaction equation
[F:1][C:2]1[CH:30]=[CH:29][C:5]([CH2:6][N:7]2[C:12](=[O:13])[C:11]([CH2:14]OS(C)(=O)=O)=[CH:10][C:9]([C:20]3[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[C:22]([F:28])[CH:21]=3)=[N:8]2)=[CH:4][CH:3]=1.[CH3:31][NH:32][CH3:33]>>[CH3:31][N:32]([CH2:14][C:11]1[C:12](=[O:13])[N:7]([CH2:6][C:5]2[CH:29]=[CH:30][C:2]([F:1])=[CH:3][CH:4]=2)[N:8]=[C:9]([C:20]2[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[C:22]([F:28])[CH:21]=2)[CH:10]=1)[CH3:33]

Participants

3

Reactant 2

HCID 674DimethylamineHCID 219916762-(4-fluorobenzyl)-6-(3-fluoro-4-methoxyphenyl)-4-methanesulfonyloxymethyl-2H-pyridazin-3-one

Product 1

HCID 102714024-dimethylaminomethyl-2-(4-fluorobenzyl)-6-(3-fluoro-4-methoxyphenyl)-2H-pyridazin-3-oneYield 60.8%

Procedure

Following the procedure of Example 7, 2-(4-fluorobenzyl)-6-(3-fluoro-4-methoxyphenyl)-4-methanesulfonyloxymethyl-2H-pyridazin-3-one and dimethylamine were reacted to yield the title compound as a slightly-yellow crystalline powder (yield: 60.8%).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-bee39e7f05844292ae39bee8e9a5d235
Source dataset
uspto-grants-2006_08
Patent number
US07087606B2

Reaction notes

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