Methanol → HCID 178428393, compound

HRID 80137Notes

Reaction equation

HRID 80137 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[N:8]1[CH2:12][CH2:11][N:10]([C:13]2[CH:29]=[CH:28][C:16]3[N:17](COCC[Si](C)(C)C)[CH:18]=[N:19][C:15]=3[CH:14]=2)[C:9]1=[O:30].CO>Cl.O1CCOCC1.C(Cl)(Cl)Cl>[NH:17]1[C:16]2[CH:28]=[CH:29][C:13]([N:10]3[CH2:11][CH2:12][N:8]([C:3]4[CH:4]=[N:5][CH:6]=[CH:7][C:2]=4[CH3:1])[C:9]3=[O:30])=[CH:14][C:15]=2[N:19]=[CH:18]1

Participants

5

Reactant 2

HCID 887MethanolHCID 68786548HCID 68786548, compound

Product 1

HCID 178428393HCID 178428393, compoundYield 46.8%

Reagents, catalysts & solvents 2

HCID 6212ChloroformSolventHCID 204431481,4-Dioxane hydrochlorideSolvent

Procedure

1-(4-Methyl-pyridin-3-yl)-3-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-benzoimidazol-5-yl]-imidazolidin-2-one (260 mg, 0.6138 mmol) in 1,4-dioxane hydrochloride (15 mL) was taken in a reaction flask and the flask was stirred at room temperature for 12 hours. The reaction was monitored by TLC (10% MeOH in CHCl3). The reaction mixture was concentrated under reduced pressure and the concentrate was washed with diethyl ether and hexane to afford 26 mg of the product (46.8% yield).

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. washthe concentrate was washed with diethyl ether and hexane

Sources & evidence

ORD record
ord-ceef6f2a3c0d403b859b3f59eb058ab2
Source dataset
uspto-grants-2014_09
Patent number
USRE045173E1

Reaction notes

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