1,4-Dioxaspiro[4.5]decan-8-one → N-(1-(4-hydroxy-4-(isothiazol-5-yl)cyclohexyl)azetidin-3-yl)-2-((6-(trifluoromethyl)quinazolin-4-yl)amino)acetamide

HRID 801441Notes

Reaction equation

[Br:14][c:15]1[s:16][n:17][cH:18][cH:19]1.[NH:31]1[CH2:32][CH:33]([NH:35][C:36]([CH2:37][NH:38][c:39]2[n:40][cH:41][n:42][c:43]3[cH:44][cH:45][c:46]([C:49]([F:50])([F:51])[F:52])[cH:47][c:48]23)=[O:53])[CH2:34]1.[O:20]1[C:21]2([CH2:22][CH2:23][C:24](=[O:25])[CH2:26][CH2:27]2)[O:28][CH2:29][CH2:30]1.[OH:1][C:2]1([c:9]2[cH:10][cH:11][n:12][s:13]2)[CH2:3][CH2:4][C:5](=[O:8])[CH2:6][CH2:7]1>>[OH:1][C:2]1([c:9]2[cH:10][cH:11][n:12][s:13]2)[CH2:3][CH2:4][CH:5]([N:31]2[CH2:32][CH:33]([NH:35][C:36]([CH2:37][NH:38][c:39]3[n:40][cH:41][n:42][c:43]4[cH:44][cH:45][c:46]([C:49]([F:50])([F:51])[F:52])[cH:47][c:48]34)=[O:53])[CH2:34]2)[CH2:6][CH2:7]1