Methanol → 3-Methyl-4-(trifluoromethyl)-4-piperidinol

HRID 801611Notes

Reaction equation

HRID 801611 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH2:9][CH:10]([CH3:19])[C:11]([C:14]([F:15])([F:16])[F:17])([OH:18])[CH2:12][CH2:13]1.[CH3:20][OH:21].[H:22][H:23].[OH-:24].[OH-:26].[Pd+2:25]>>[NH:8]1[CH2:9][CH:10]([CH3:19])[C:11]([C:14]([F:15])([F:16])[F:17])([OH:18])[CH2:12][CH2:13]1

Participants

6

Reactant 5

HCID 887MethanolHCID 961Hydroxide2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 23003721HCID 23003721, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 230036553-Methyl-4-(trifluoromethyl)-4-piperidinol

Sources & evidence

ORD record
ord-1268cfef294f48cf83b007f51324b7a4
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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