6-(2,4-difluorophenyl)-2-isobutyl-4-methanesulfonyloxym ethyl-2H-pyridazin-3-one → 4-carboxy-6-(3-fluoro-4-methoxyphenyl)-2-[3-(4-fluorophenyl)propyl]-2H-pyridazin-3-one

HRID 8017Notes

Reaction equation

HRID 8017 reaction equation
FC1C=C(F)C=CC=1C1C=C(COS(C)(=O)=O)C(=O)N(CC(C)C)N=1.[F:26][C:27]1[CH:28]=[C:29]([C:35]2[CH:36]=[C:37]([C:52]([O:54]C)=[O:53])[C:38](=[O:51])[N:39]([CH2:41][CH2:42][CH2:43][C:44]3[CH:49]=[CH:48][C:47]([F:50])=[CH:46][CH:45]=3)[N:40]=2)[CH:30]=[CH:31][C:32]=1[O:33][CH3:34]>>[C:52]([C:37]1[C:38](=[O:51])[N:39]([CH2:41][CH2:42][CH2:43][C:44]2[CH:49]=[CH:48][C:47]([F:50])=[CH:46][CH:45]=2)[N:40]=[C:35]([C:29]2[CH:30]=[CH:31][C:32]([O:33][CH3:34])=[C:27]([F:26])[CH:28]=2)[CH:36]=1)([OH:54])=[O:53]

Participants

3

Reactant 2

HCID 219914166-(2,4-difluorophenyl)-2-isobutyl-4-methanesulfonyloxym ethyl-2H-pyridazin-3-oneHCID 219914616-(3-fluoro-4-methoxyphenyl)-2-[3-(4-fluorophenyl)propyl]-4-methoxycarbonyl-2H-pyridazin-3-one

Product 1

HCID 219916374-carboxy-6-(3-fluoro-4-methoxyphenyl)-2-[3-(4-fluorophenyl)propyl]-2H-pyridazin-3-oneYield 89.2%

Procedure

Following the procedure of Example 1 (7), 6-(3-fluoro-4-methoxyphenyl)-2-[3-(4-fluorophenyl)propyl]-4-methoxycarbonyl-2H-pyridazin-3-one was reacted to yield the title compound as a yellow powder (yield: 89.2%).

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-72d462986a3041f7b6769f8b11c4c5ad
Source dataset
uspto-grants-2006_08
Patent number
US07087606B2

Reaction notes

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