methyl 3-amino-5-(trifluoromethyl)benzoate → 5-fluoro-N4-(3-hydroxyphenyl)-N2-(3-methoxycarbonyl-5-trifluoromethylphenyl)-2,4-pyrimidinediamine

HRID 801714Notes

Reaction equation

HRID 801714 reaction equation
[CH3:17][O:18][C:19](=[O:20])[c:21]1[cH:22][c:23]([NH2:24])[cH:25][c:26]([C:28]([F:29])([F:30])[F:31])[cH:27]1.[Cl:1][c:2]1[n:3][cH:4][c:5]([F:16])[c:6]([NH:8][c:9]2[cH:10][c:11]([OH:15])[cH:12][cH:13][cH:14]2)[n:7]1>>[c:2]1([NH:24][c:23]2[cH:22][c:21]([C:19]([O:18][CH3:17])=[O:20])[cH:27][c:26]([C:28]([F:29])([F:30])[F:31])[cH:25]2)[n:3][cH:4][c:5]([F:16])[c:6]([NH:8][c:9]2[cH:10][c:11]([OH:15])[cH:12][cH:13][cH:14]2)[n:7]1

Participants

3

Reactant 2

HCID 4026781methyl 3-amino-5-(trifluoromethyl)benzoateHCID 220604512-chloro-5-fluoro-N-(3-hydroxyphenyl)-4-pyrimidineamine

Product 1

HCID 220610955-fluoro-N4-(3-hydroxyphenyl)-N2-(3-methoxycarbonyl-5-trifluoromethylphenyl)-2,4-pyrimidinediamine

Sources & evidence

ORD record
ord-c005ad13f5d34470a0ad8db90f81b4df
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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