2-isobutyl-6-(2,4-difluorophenyl)-4-phthalimidomethyl-2H-pyridazin-3-one → 6-(3-fluoro-4-methoxyphenyl)-2-[3-(4-fluorophenyl)propyl]-4-hydroxymethyl-2H-pyridazin-3-one

HRID 8018Notes

Reaction equation

HRID 8018 reaction equation
FC1C=C(F)C=CC=1C1C=C(CN2C(=O)C3=CC=CC=C3C2=O)C(=O)N(CC(C)C)N=1.[C:32]([C:35]1[C:36](=[O:60])[N:37]([CH2:50][CH2:51][CH2:52][C:53]2[CH:58]=[CH:57][C:56]([F:59])=[CH:55][CH:54]=2)[N:38]=[C:39]([C:41]2[CH:46]=[CH:45][C:44]([O:47][CH3:48])=[C:43]([F:49])[CH:42]=2)[CH:40]=1)(O)=[O:33]>>[F:49][C:43]1[CH:42]=[C:41]([C:39]2[CH:40]=[C:35]([CH2:32][OH:33])[C:36](=[O:60])[N:37]([CH2:50][CH2:51][CH2:52][C:53]3[CH:54]=[CH:55][C:56]([F:59])=[CH:57][CH:58]=3)[N:38]=2)[CH:46]=[CH:45][C:44]=1[O:47][CH3:48]

Participants

3

Reactant 2

HCID 219915872-isobutyl-6-(2,4-difluorophenyl)-4-phthalimidomethyl-2H-pyridazin-3-oneHCID 219916374-carboxy-6-(3-fluoro-4-methoxyphenyl)-2-[3-(4-fluorophenyl)propyl]-2H-pyridazin-3-one

Product 1

HCID 219915096-(3-fluoro-4-methoxyphenyl)-2-[3-(4-fluorophenyl)propyl]-4-hydroxymethyl-2H-pyridazin-3-oneYield 37%

Procedure

Following the procedure of Example 1 (8), 4-carboxy-6-(3-fluoro-4-methoxyphenyl)-2-[3-(4-fluorophenyl)propyl]-2H-pyridazin-3-one was reacted to yield the title compound as a yellow powder (yield: 37.0%).

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-b0d283c8f3cd40afb9343776db9308af
Source dataset
uspto-grants-2006_08
Patent number
US07087606B2

Reaction notes

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