Dimethylamine → HCID 10136451, compound

HRID 8020Notes

Reaction equation

HRID 8020 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:10]2[CH:11]=[C:12]([CH2:27]OS(C)(=O)=O)[C:13](=[O:26])[N:14]([CH2:16][CH2:17][CH2:18][C:19]3[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=3)[N:15]=2)[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].[CH3:33][NH:34][CH3:35]>>[CH3:33][N:34]([CH2:27][C:12]1[C:13](=[O:26])[N:14]([CH2:16][CH2:17][CH2:18][C:19]2[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=2)[N:15]=[C:10]([C:4]2[CH:5]=[CH:6][C:7]([O:8][CH3:9])=[C:2]([F:1])[CH:3]=2)[CH:11]=1)[CH3:35]

Participants

3

Reactant 2

HCID 674DimethylamineHCID 219916146-(3-Fluoro-4-methoxyphenyl)-2-[3-(4-fluorophenyl)propyl]-4-methanesulfonyloxymethyl-2h-pyridazin-3-one

Product 1

HCID 10136451HCID 10136451, compoundYield 61.8%

Procedure

Following the procedure of Example 7, 6-(3-fluoro-4-methoxyphenyl)-2-[3-(4-fluorophenyl)propyl]-4-methanesulfonyloxymethyl-2H-pyridazin-3-one and dimethylamine were reacted to yield the title compound as a pale yellow crystalline powder (yield: 61.8%).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-e10a6d32b3d740e695807ccc89fba89b
Source dataset
uspto-grants-2006_08
Patent number
US07087606B2

Reaction notes

Loading…