Acetic Acid → 3-(1-Methyl-piperidin-4-ylamino)-5-phenyl-thiophene-2-carboxylic acid methyl ester

HRID 802022Notes

Reaction equation

HRID 802022 reaction equation
[C:29]([OH:30])(=[O:31])[CH3:32].[CH3:17][N:18]1[CH2:19][CH2:20][C:21]([O:24][Si:25]([CH3:26])([CH3:27])[CH3:28])=[CH:22][CH2:23]1.[CH3:1][O:2][C:3](=[O:4])[c:5]1[s:6][c:7](-[c:11]2[cH:12][cH:13][cH:14][cH:15][cH:16]2)[cH:8][c:9]1[NH2:10].[Cl:35][CH:36]([Cl:37])[CH3:38].[Na+:34].[OH-:33]>>[CH3:1][O:2][C:3](=[O:4])[c:5]1[s:6][c:7](-[c:11]2[cH:12][cH:13][cH:14][cH:15][cH:16]2)[cH:8][c:9]1[NH:10][CH:21]1[CH2:20][CH2:19][N:18]([CH3:17])[CH2:23][CH2:22]1

Participants

7

Reactant 6

HCID 176Acetic AcidHCID 923Sodium ionHCID 961HydroxideHCID 63651,1-DichloroethaneHCID 700562Methyl 3-amino-5-phenylthiophene-2-carboxylateHCID 100811201-Methyl-4-trimethylsilanyloxy-1,2,3,6-tetrahydro-pyridine

Product 1

HCID 207757493-(1-Methyl-piperidin-4-ylamino)-5-phenyl-thiophene-2-carboxylic acid methyl ester

Sources & evidence

ORD record
ord-8e0f48c180964ae0ae1eae03c4463cbf
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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