4-(3,4-Difluorophenoxy)benzaldehyde → N-(3-{1-[4-(3,4-difluorophenoxy)benzyl]-4-piperidinyl}phenyl)-2-methylpropanamide
Reaction equation
[CH3:18][CH:19]([C:20](=[O:21])[NH:22][c:23]1[cH:24][c:25]([CH:29]2[CH2:30][CH2:31][NH:32][CH2:33][CH2:34]2)[cH:26][cH:27][cH:28]1)[CH3:35].[F:1][c:2]1[cH:3][c:4]([O:5][c:6]2[cH:7][cH:8][c:9]([CH:10]=[O:11])[cH:12][cH:13]2)[cH:14][cH:15][c:16]1[F:17]>>[F:1][c:2]1[cH:3][c:4]([O:5][c:6]2[cH:7][cH:8][c:9]([CH2:10][N:32]3[CH2:31][CH2:30][CH:29]([c:25]4[cH:24][c:23]([NH:22][C:20]([CH:19]([CH3:18])[CH3:35])=[O:21])[cH:28][cH:27][cH:26]4)[CH2:34][CH2:33]3)[cH:12][cH:13]2)[cH:14][cH:15][c:16]1[F:17]Participants
3
Sources & evidence
- ORD record
- ord-500fab47023447d2a7a2099e00480129
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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