Acetonitrile → 7-Hydroxy Risperidone

HRID 802167Notes

Reaction equation

[CH3:38][C:39]#[N:40].[F:1][c:2]1[cH:3][c:4]2[c:5]([c:6]([CH:9]3[CH2:10][CH2:11][N:12]([CH2:15][CH2:16][c:17]4[c:18]([CH3:30])[n:19][c:20]5[n:21]([c:22]4=[O:23])[CH2:24][CH:25]([O:28][CH3:29])[CH2:26][CH2:27]5)[CH2:13][CH2:14]3)[n:7][o:8]2)[cH:31][cH:32]1.[I:33][Si:34]([CH3:35])([CH3:36])[CH3:37]>>[F:1][c:2]1[cH:3][c:4]2[c:5]([c:6]([CH:9]3[CH2:10][CH2:11][N:12]([CH2:15][CH2:16][c:17]4[c:18]([CH3:30])[n:19][c:20]5[n:21]([c:22]4=[O:23])[CH2:24][CH:25]([OH:28])[CH2:26][CH2:27]5)[CH2:13][CH2:14]3)[n:7][o:8]2)[cH:31][cH:32]1

Participants

Reactant 3

HCID 6342Acetonitrile

HCID 85247Trimethylsilyl iodide

HCID 183536403-{2-[4-(6-Fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-7-methoxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one

Product 1

HCID 4751007-Hydroxy Risperidone

Sources & evidence

ORD record: ord-5a6c60c1d9cd4661a42ff533d4b6d205
Source dataset: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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