2-(Methoxymethyl)pyrrolidine → 1-(Benzo[d][1,3]dioxol-5-yl)-N-(5-((2-(methoxymethyl)pyrrolidin-1-yl)(2-methoxyphenyl)methyl)pyridin-2-yl)cyclopropanecarboxamide

HRID 802383Notes

Reaction equation

HRID 802383 reaction equation
[CH3:1][S:2]([O:3][CH:6]([c:7]1[c:8]([O:13][CH3:14])[cH:9][cH:10][cH:11][cH:12]1)[c:15]1[cH:16][n:17][c:18]([NH:21][C:22](=[O:23])[C:24]2([c:27]3[cH:28][c:29]4[c:30]([cH:34][cH:35]3)[O:31][CH2:32][O:33]4)[CH2:25][CH2:26]2)[cH:19][cH:20]1)(=[O:4])=[O:5].[CH3:36][O:37][CH2:38][CH:39]1[NH:40][CH2:41][CH2:42][CH2:43]1.[O:44]1[c:45]2[cH:46][cH:47][c:48]([C:49]3([C:50]([NH:51][c:52]4[cH:53][cH:54][c:55]([CH:56]([N:57]([CH3:58])[CH3:59])[c:60]5[cH:61][cH:62][cH:63][cH:64][c:65]5[O:66][CH3:67])[cH:68][n:69]4)=[O:70])[CH2:71][CH2:72]3)[cH:73][c:74]2[O:75][CH2:76]1>>[CH:6]([c:7]1[c:8]([O:13][CH3:14])[cH:9][cH:10][cH:11][cH:12]1)([c:15]1[cH:16][n:17][c:18]([NH:21][C:22](=[O:23])[C:24]2([c:27]3[cH:28][c:29]4[c:30]([cH:34][cH:35]3)[O:31][CH2:32][O:33]4)[CH2:25][CH2:26]2)[cH:19][cH:20]1)[N:40]1[CH:39]([CH2:38][O:37][CH3:36])[CH2:43][CH2:42][CH2:41]1

Participants

4

Reactant 3

HCID 1439532-(Methoxymethyl)pyrrolidineHCID 442364971-(benzo[d][1,3]dioxol-5-yl)-N-(5-((dimethylamino)(2-methoxyphenyl)methyl)pyridin-2-yl)cyclopropanecarboxamideHCID 57895126(6-(1-(Benzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)pyridin-3-yl)(2-methoxyphenyl)methyl methanesulfonate

Product 1

HCID 442366241-(Benzo[d][1,3]dioxol-5-yl)-N-(5-((2-(methoxymethyl)pyrrolidin-1-yl)(2-methoxyphenyl)methyl)pyridin-2-yl)cyclopropanecarboxamide

Sources & evidence

ORD record
ord-bb54a7751a544123bc4ceb67059319b7
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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