4-(Bromomethyl)-1,2-difluorobenzene → 2-(3,4-difluorobenzyl)-6-(3-fluoro-4-methoxyphenyl)-4-methoxycarbonyl-2H-pyridazin-3-one

HRID 8028Notes

Reaction equation

HRID 8028 reaction equation
FC1C=C(F)C=CC=1C1C=C(CO)C(=O)N(CC(C)C)N=1.[F:22][C:23]1[CH:24]=[C:25]([C:31]2[CH:32]=[C:33]([C:38]([O:40][CH3:41])=[O:39])[C:34](=[O:37])[NH:35][N:36]=2)[CH:26]=[CH:27][C:28]=1[O:29][CH3:30].[F:42][C:43]1[CH:44]=[C:45]([CH:48]=[CH:49][C:50]=1[F:51])[CH2:46]Br>>[F:42][C:43]1[CH:44]=[C:45]([CH:48]=[CH:49][C:50]=1[F:51])[CH2:46][N:35]1[C:34](=[O:37])[C:33]([C:38]([O:40][CH3:41])=[O:39])=[CH:32][C:31]([C:25]2[CH:26]=[CH:27][C:28]([O:29][CH3:30])=[C:23]([F:22])[CH:24]=2)=[N:36]1

Participants

4

Reactant 3

HCID 5814364-(Bromomethyl)-1,2-difluorobenzeneHCID 219914326-(3-fluoro-4-methoxyphenyl)-4-methoxycarbonyl-2H-pyridazin-3-oneHCID 219916626-(2,4-difluorophenyl)-4-hydroxymethyl-2-isobutyl-2H-pyridazin-3-one

Product 1

HCID 219916662-(3,4-difluorobenzyl)-6-(3-fluoro-4-methoxyphenyl)-4-methoxycarbonyl-2H-pyridazin-3-oneYield 92.1%

Procedure

Following the procedure of Example 1 (6), 6-(3-fluoro-4-methoxyphenyl)-4-methoxycarbonyl-2H-pyridazin-3-one and 3,4-difluorobenzyl bromide were reacted to yield the title compound as a yellow crystalline powder (yield: 92.1%)

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-7fbe98d2d8c545b9967357d14a5f9904
Source dataset
uspto-grants-2006_08
Patent number
US07087606B2

Reaction notes

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