4-carboxy-2-(3,4-difluorobenzyl)-6-(3-fluoro-4-methoxyphenyl)-2H-pyridazin-3-one → 2-(3,4-difluorobenzyl)-6-(3-fluoro-4-methoxyphenyl)-4-hydroxymethyl-2H-pyridazin-3-one

HRID 8030Notes

Reaction equation

HRID 8030 reaction equation
FC1C=C(F)C=CC=1C1C=C(CN2C(=O)C3=CC=CC=C3C2=O)C(=O)N(CC(C)C)N=1.[C:32]([C:35]1[C:36](=[O:59])[N:37]([CH2:50][C:51]2[CH:56]=[CH:55][C:54]([F:57])=[C:53]([F:58])[CH:52]=2)[N:38]=[C:39]([C:41]2[CH:46]=[CH:45][C:44]([O:47][CH3:48])=[C:43]([F:49])[CH:42]=2)[CH:40]=1)(O)=[O:33]>>[F:58][C:53]1[CH:52]=[C:51]([CH:56]=[CH:55][C:54]=1[F:57])[CH2:50][N:37]1[C:36](=[O:59])[C:35]([CH2:32][OH:33])=[CH:40][C:39]([C:41]2[CH:46]=[CH:45][C:44]([O:47][CH3:48])=[C:43]([F:49])[CH:42]=2)=[N:38]1

Participants

3

Reactant 2

HCID 219914784-carboxy-2-(3,4-difluorobenzyl)-6-(3-fluoro-4-methoxyphenyl)-2H-pyridazin-3-oneHCID 219915872-isobutyl-6-(2,4-difluorophenyl)-4-phthalimidomethyl-2H-pyridazin-3-one

Product 1

HCID 219914222-(3,4-difluorobenzyl)-6-(3-fluoro-4-methoxyphenyl)-4-hydroxymethyl-2H-pyridazin-3-oneYield 7.7%

Procedure

Following the procedure of Example 1 (8), 4-carboxy-2-(3,4-difluorobenzyl)-6-(3-fluoro-4-methoxyphenyl)-2H-pyridazin-3-one was reacted to yield the title compound as slightly-yellow neeldes (yield: 7.7%).

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-c222847b90d34f32a09c7626c75e0038
Source dataset
uspto-grants-2006_08
Patent number
US07087606B2

Reaction notes

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