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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 803119Generated: October 31, 2026

Dimethylformamide → 5-Chloro-N-{2-[1-(cyanomethyl)-4-piperidinyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}-2-thiophenecarboxamide

https://huagongshe.com/reaction/803119

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDimethylformamideHCID 6228—
ReactantTriethylamineHCID 8471—
ReactantBromoacetonitrileHCID 11534—
Reactant5-chloro-N-[1,3-dioxo-2-(4-piperidinyl)-2,3-dihydro-1H-isoindol-4-yl]-2-thiophenecarboxamideHCID 12074893—
Product5-Chloro-N-{2-[1-(cyanomethyl)-4-piperidinyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}-2-thiophenecarboxamideHCID 12073245—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTest data from https://doi.org/10.1039/C8SC04228D
ORD IDord-8be436d51ea84a89a7171380253834bc
Source noteTest data from https://doi.org/10.1039/C8SC04228D