Dimethylamine → HCID 10135779, compound

HRID 8032Notes

Reaction equation

[F:1][C:2]1[CH:3]=[C:4]([CH:28]=[CH:29][C:30]=1[F:31])[CH2:5][N:6]1[C:11](=[O:12])[C:10]([CH2:13]OS(C)(=O)=O)=[CH:9][C:8]([C:19]2[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[C:21]([F:27])[CH:20]=2)=[N:7]1.[CH3:32][NH:33][CH3:34]>>[F:1][C:2]1[CH:3]=[C:4]([CH:28]=[CH:29][C:30]=1[F:31])[CH2:5][N:6]1[C:11](=[O:12])[C:10]([CH2:13][N:33]([CH3:34])[CH3:32])=[CH:9][C:8]([C:19]2[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[C:21]([F:27])[CH:20]=2)=[N:7]1

Participants

Reactant 2

HCID 674Dimethylamine

HCID 21991516HCID 21991516, compound

Product 1

HCID 10135779HCID 10135779, compoundYield 77.1%

Procedure

Following the procedure of Example 7, 2-(3, 4-difluorobenzyl)-6-(3-fluoro-4-methoxyphenyl)-4-methanesulfonyloxymethyl-2H-pyridazin-3-one and dimethylamine were reacted to yield the title compound as slightly-yellow needles (yield: 77.1%).

Workup

customwere reacted

Sources & evidence

ORD record: ord-219d580ddc064d6bb4eb4be881f5728d
Source dataset: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07087606B2

Reaction notes

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