3-Fluorobenzyl bromide → 6-Chloro-1-(3-fluorobenzyl)-2-oxo-4-[4-(thiophene-2-carbonyl)-piperazin-1-yl]-1,2-dihydro-[1,8]-naphthyridine-3-carbonitrile
Reaction equation
[Cl:1][c:2]1[cH:3][c:4]2[c:5]([N:15]3[CH2:16][CH2:17][N:18]([C:21](=[O:22])[c:23]4[s:24][cH:25][cH:26][cH:27]4)[CH2:19][CH2:20]3)[c:6]([C:13]#[N:14])[c:7](=[O:12])[nH:8][c:9]2[n:10][cH:11]1.[F:28][c:29]1[cH:30][c:31]([CH2:32][Br:33])[cH:34][cH:35][cH:36]1>>[Cl:1][c:2]1[cH:3][c:4]2[c:5]([N:15]3[CH2:16][CH2:17][N:18]([C:21](=[O:22])[c:23]4[s:24][cH:25][cH:26][cH:27]4)[CH2:19][CH2:20]3)[c:6]([C:13]#[N:14])[c:7](=[O:12])[n:8]([CH2:32][c:31]3[cH:30][c:29]([F:28])[cH:36][cH:35][cH:34]3)[c:9]2[n:10][cH:11]1Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-cc4b72e6ee5f466ca29a8fe574fee427
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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