Benzylamine → 2-oxo-3-(N-benzylamino)methylenetetrahydrofuran

HRID 80327Notes

Reaction equation

HRID 80327 reaction equation
[Na].O[CH:3]=[C:4]1[CH2:8][CH2:7][O:6][C:5]1=[O:9].[CH2:10]([NH2:17])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>>[CH2:10]([NH:17][CH:3]=[C:4]1[CH2:8][CH2:7][O:6][C:5]1=[O:9])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Participants

3

Reactant 2

HCID 7504BenzylamineHCID 66988753HCID 66988753, compound

Product 1

HCID 669882902-oxo-3-(N-benzylamino)methylenetetrahydrofuran

Procedure

Using 3-hydroxymethylenedihydrofuran-2-one sodium salt (50 mmol) and benzylamine (55 mmol) and using the abovementioned method A1, 3-benzylaminomethylenedihydrofuran-2-one is produced (7.50 g, efficiency: 70%) in the form of a white powder.

Sources & evidence

ORD record
ord-aa542a49054c43f796629f0d4a6b1106
Source dataset
uspto-grants-2014_09
Patent number
US08846125B2

Reaction notes

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