Benzylamine → 2-oxo-3-(N-benzylamino)methylenetetrahydrofuran

HRID 80328Notes

Reaction equation

HRID 80328 reaction equation
[CH3:1][N:2]([CH:4]=[C:5]1[CH2:9][CH2:8][O:7][C:6]1=[O:10])C.C(N)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>>[CH2:1]([NH:2][CH:4]=[C:5]1[CH2:9][CH2:8][O:7][C:6]1=[O:10])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 7504BenzylamineHCID 3045663-Dimethylaminomethylenedihydrofuran-2-one

Product 1

HCID 669882902-oxo-3-(N-benzylamino)methylenetetrahydrofuranYield 89%

Procedure

Alternatively, using the abovementioned method B and using 3-dimethylaminomethylenedihydrofuran-2-one (10 mmol) and benzylamine (10 mmol), 3-benzylaminomethylenedihydrofuran-2-one (1.80 g, efficiency: 89%) is produced in the form of a pale yellow powder.

Sources & evidence

ORD record
ord-7aefe59359bc4f709b731e923abcfaa7
Source dataset
uspto-grants-2014_09
Patent number
US08846125B2

Reaction notes

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