7-Bromo-5-fluoroindolin-2-one → 2-(7-bromo-5-fluoro-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-3-methyl-5-(2-pyrrolidin-1-yl-ethyl)-5,6,7,8-tetrahydro-1H-pyrrolo[3,2-c]azepin-4-one

HRID 803369Notes

Reaction equation

HRID 803369 reaction equation
[Br:22][c:23]1[cH:24][c:25]([F:33])[cH:26][c:27]2[c:31]1[NH:30][C:29](=[O:32])[CH2:28]2.[CH3:1][c:2]1[c:3]([CH:20]=[O:21])[nH:4][c:5]2[c:6]1[C:7](=[O:19])[N:8]([CH2:12][CH2:13][N:14]1[CH2:15][CH2:16][CH2:17][CH2:18]1)[CH2:9][CH2:10][CH2:11]2>>[CH3:1][c:2]1[c:3]([CH:20]=[C:28]2[c:27]3[cH:26][c:25]([F:33])[cH:24][c:23]([Br:22])[c:31]3[NH:30][C:29]2=[O:32])[nH:4][c:5]2[c:6]1[C:7](=[O:19])[N:8]([CH2:12][CH2:13][N:14]1[CH2:15][CH2:16][CH2:17][CH2:18]1)[CH2:9][CH2:10][CH2:11]2

Participants

3

Reactant 2

HCID 534188887-Bromo-5-fluoroindolin-2-oneHCID 592500963-Methyl-4-oxo-5-(2-pyrrolidin-1-yl-ethyl)-1,4,5,6,7,8-hexahydro-pyrrolo[3,2-c]azepine-2-carbaldehyde

Product 1

HCID 685275972-(7-bromo-5-fluoro-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-3-methyl-5-(2-pyrrolidin-1-yl-ethyl)-5,6,7,8-tetrahydro-1H-pyrrolo[3,2-c]azepin-4-one

Sources & evidence

ORD record
ord-135d2c4ceb9245aeabaa41afb96b08f9
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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