HRID8037

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7677

1-Piperazineethanol

C6H14N2O

结构：Cc1ccc(-c2nn(CC(C)C)c(=O)c(N3CCN(C(=O)OC(C)(C)C)CC3)c2C)cc1F

HCID67214099

未命名化合物

结构：COc1ccc(-c2cc(COS(C)(=O)=O)c(=O)n(CC=Cc3ccc(Cl)cc3)n2)cc1F

HCID73858284

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(-c2cc(CN3CCN(CCO)CC3)c(=O)n(CC=Cc3ccc(Cl)cc3)n2)cc1F

HCID67213400

未命名化合物

收率 65.1%

PROCEDURE

实验过程

Following the procedure of Example 1 (10), 2-(4-chlorocinnamyl)-6-(3-fluoro-4-methoxyphenyl)-4-methanesulfonyloxymethyl-2H-pyridazin-3-one and 1-piperazineethanol were reacted to yield the title compound as slightly-yellow needles (yield: 65.1%).

WORKUP

后处理

customwere reacted

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-05e673c9e6fa437aa9ab215ba6dafd87
来源数据集: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07087606B2
来源说明: uspto-grants-2006_08

反应 SMILES

C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[C:15](=[O:33])N(CC(C)C)N=C(C3C=CC(C)=C(F)C=3)C=2C)[CH2:10][CH2:9]1)=O)(C)(C)C.[Cl:34][C:35]1[CH:65]=[CH:64][C:38]([CH:39]=[CH:40][CH2:41][N:42]2[C:47](=[O:48])[C:46]([CH2:49]OS(C)(=O)=O)=[CH:45][C:44]([C:55]3[CH:60]=[CH:59][C:58]([O:61][CH3:62])=[C:57]([F:63])[CH:56]=3)=[N:43]2)=[CH:37][CH:36]=1.N1(CCO)CCNCC1>>[Cl:34][C:35]1[CH:36]=[CH:37][C:38]([CH:39]=[CH:40][CH2:41][N:42]2[C:47](=[O:48])[C:46]([CH2:49][N:8]3[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][OH:33])[CH2:10][CH2:9]3)=[CH:45][C:44]([C:55]3[CH:60]=[CH:59][C:58]([O:61][CH3:62])=[C:57]([F:63])[CH:56]=3)=[N:43]2)=[CH:64][CH:65]=1