2-(Trifluoromethylthio)ethyl Trifluoromethanesulfonate → 2-(6-Trifluoromethyl-pyridin-3-ylmethanesulfonyl)-4-trifluoromethylsulfanyl-butyronitrile

HRID 80407Notes

Reaction equation

HRID 80407 reaction equation
[F:1][C:2]([F:17])([F:16])[C:3]1[N:8]=[CH:7][C:6]([CH2:9][S:10]([CH2:13][C:14]#[N:15])(=[O:12])=[O:11])=[CH:5][CH:4]=1.[F:18][C:19]([S:22][CH2:23][CH2:24]OS(C(F)(F)F)(=O)=O)([F:21])[F:20]>>[F:17][C:2]([F:1])([F:16])[C:3]1[N:8]=[CH:7][C:6]([CH2:9][S:10]([CH:13]([CH2:24][CH2:23][S:22][C:19]([F:21])([F:20])[F:18])[C:14]#[N:15])(=[O:11])=[O:12])=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 252420282-(Trifluoromethylthio)ethyl TrifluoromethanesulfonateHCID 67226638HCID 67226638, compound

Product 1

HCID 532364812-(6-Trifluoromethyl-pyridin-3-ylmethanesulfonyl)-4-trifluoromethylsulfanyl-butyronitrile

Procedure

Compound II-9 was prepared from (6-trifluoromethyl-pyridin-3-ylmethanesulfonyl)-acetonitrile and trifluoro-methanesulfonic acid 2-trifluoromethylsulfanyl-ethyl ester as described for compound II-1.

Sources & evidence

ORD record
ord-91e166a743ba4135b34420db58a5da7d
Source dataset
uspto-grants-2014_09
Patent number
US08846569B2

Reaction notes

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