1-Butanol → tert-butyl N-[1-[5-bromo-3-[[1-[(4-methoxyphenyl)methyl]pyrazole-4-carbonyl]amino]-1H-pyrrolo[2,3-b]pyridin-4-yl]piperidin-3-yl]carbamate

HRID 804089Notes

Reaction equation

HRID 804089 reaction equation
[Br:1][c:2]1[c:3]([F:28])[c:4]2[c:5]([n:6][cH:7]1)[nH:8][cH:9][c:10]2[NH:11][C:12](=[O:13])[c:14]1[cH:15][n:16][n:17]([CH2:19][c:20]2[cH:21][cH:22][c:23]([O:26][CH3:27])[cH:24][cH:25]2)[cH:18]1.[CH2:43]([OH:44])[CH2:45][CH2:46][CH3:47].[NH:29]1[CH2:30][CH:31]([NH:35][C:36]([O:37][C:38]([CH3:39])([CH3:40])[CH3:41])=[O:42])[CH2:32][CH2:33][CH2:34]1>>[Br:1][c:2]1[c:3]([N:29]2[CH2:30][CH:31]([NH:35][C:36]([O:37][C:38]([CH3:39])([CH3:40])[CH3:41])=[O:42])[CH2:32][CH2:33][CH2:34]2)[c:4]2[c:5]([n:6][cH:7]1)[nH:8][cH:9][c:10]2[NH:11][C:12](=[O:13])[c:14]1[cH:15][n:16][n:17]([CH2:19][c:20]2[cH:21][cH:22][c:23]([O:26][CH3:27])[cH:24][cH:25]2)[cH:18]1

Participants

4

Reactant 3

HCID 2631-ButanolHCID 42330413-(Boc-amino)piperidineHCID 60205476N-(5-bromo-4-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-(4-methoxybenzyl)-1H-pyrazole-4-carboxamide

Product 1

HCID 60205477tert-butyl N-[1-[5-bromo-3-[[1-[(4-methoxyphenyl)methyl]pyrazole-4-carbonyl]amino]-1H-pyrrolo[2,3-b]pyridin-4-yl]piperidin-3-yl]carbamate

Sources & evidence

ORD record
ord-5c16aac4e279485780c50eb8ab15a1b4
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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