4-(2-carboxyethyl)-2-cyclopropylmethyl-6-(3-fluoro-4-methoxyphenyl)-2H-pyridazin-3-one → 2-cyclopropylmethyl-6-(3-fluoro-4-methoxyphenyl)-4-(3-hydroxypropyl)-2H-pyridazin-3-one

HRID 8041Notes

Reaction equation

HRID 8041 reaction equation
FC1C=C(F)C=CC=1C1C=C(CN2C(=O)C3=CC=CC=C3C2=O)C(=O)N(CC(C)C)N=1.[C:32]([CH2:35][CH2:36][C:37]1[C:38](=[O:56])[N:39]([CH2:52][CH:53]2[CH2:55][CH2:54]2)[N:40]=[C:41]([C:43]2[CH:48]=[CH:47][C:46]([O:49][CH3:50])=[C:45]([F:51])[CH:44]=2)[CH:42]=1)(O)=[O:33]>>[CH:53]1([CH2:52][N:39]2[C:38](=[O:56])[C:37]([CH2:36][CH2:35][CH2:32][OH:33])=[CH:42][C:41]([C:43]3[CH:48]=[CH:47][C:46]([O:49][CH3:50])=[C:45]([F:51])[CH:44]=3)=[N:40]2)[CH2:55][CH2:54]1

Participants

3

Reactant 2

HCID 219914104-(2-carboxyethyl)-2-cyclopropylmethyl-6-(3-fluoro-4-methoxyphenyl)-2H-pyridazin-3-oneHCID 219915872-isobutyl-6-(2,4-difluorophenyl)-4-phthalimidomethyl-2H-pyridazin-3-one

Product 1

HCID 219914722-cyclopropylmethyl-6-(3-fluoro-4-methoxyphenyl)-4-(3-hydroxypropyl)-2H-pyridazin-3-oneYield 82.9%

Procedure

Following the procedure of Example 1 (8), 4-(2-carboxyethyl)-2-cyclopropylmethyl-6-(3-fluoro-4-methoxyphenyl)-2H-pyridazin-3-one was reacted to yield the title compound as a brown oil (yield: 82.9%).

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-cb5e1d7ad4974c3aabb1630f8ff71cea
Source dataset
uspto-grants-2006_08
Patent number
US07087606B2

Reaction notes

Loading…