Acetone → 2,2,2-Trichloroethyl 4-[4-(hydroxymethyl)piperidin-1-yl]butanoate

HRID 804243Notes

Reaction equation

HRID 804243 reaction equation
[Br:15][CH2:16][CH2:17][CH2:18][C:19](=[O:20])[O:21][CH2:22][C:23]([Cl:24])([Cl:25])[Cl:26].[CH3:27][C:28](=[O:29])[CH3:30].[K+:10].[K+:9].[NH:1]1[CH2:2][CH2:3][CH:4]([CH2:7][OH:8])[CH2:5][CH2:6]1.[O-:11][C:12]([O-:13])=[O:14]>>[N:1]1([CH2:16][CH2:17][CH2:18][C:19](=[O:20])[O:21][CH2:22][C:23]([Cl:24])([Cl:25])[Cl:26])[CH2:2][CH2:3][CH:4]([CH2:7][OH:8])[CH2:5][CH2:6]1

Participants

6

Reactant 5

HCID 180AcetoneHCID 813Potassium Cation2×HCID 19660Carbonate IonHCID 4207714-PiperidinemethanolHCID 111200754-Bromobutyric acid, 2,2,2-trichloroethyl ester

Product 1

HCID 574299132,2,2-Trichloroethyl 4-[4-(hydroxymethyl)piperidin-1-yl]butanoate

Sources & evidence

ORD record
ord-aa5b8012d21541589a526fdd285564e6
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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