2-Fluorophenylboronic acid → 4-[5-(2-Fluorophenyl)pyridin-3-yl]-1,4-diazatricyclo[4.3.1.13,8]undecane

HRID 80442Notes

Reaction equation

HRID 80442 reaction equation
Br[C:2]1[CH:3]=[C:4]([N:8]2[CH2:16][CH:15]3[CH2:17][N:11]4[CH2:12][CH:13]([CH2:18][CH:9]2[CH2:10]4)[CH2:14]3)[CH:5]=[N:6][CH:7]=1.[F:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1B(O)O>>[F:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[C:2]1[CH:3]=[C:4]([N:8]2[CH2:16][CH:15]3[CH2:17][N:11]4[CH2:12][CH:13]([CH2:18][CH:9]2[CH2:10]4)[CH2:14]3)[CH:5]=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 27343542-Fluorophenylboronic acidHCID 866492494-(5-Bromopyridin-3-yl)-1,4-diazatricyclo[4.3.1.13,8]undecane

Product 1

HCID 498695694-[5-(2-Fluorophenyl)pyridin-3-yl]-1,4-diazatricyclo[4.3.1.13,8]undecane

Procedure

The title compound was prepared from the product of Example 65A and 2-fluorophenylboronic acid according to General Method B: LC-MS Method D (ESI+) m/z 324.0 (M+H)+, retention time 1.30 minutes.

Sources & evidence

ORD record
ord-1b8657b2eff64c55a71fa385fe3351d8
Source dataset
uspto-grants-2014_09
Patent number
US08846661B2

Reaction notes

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