4-Cyanophenylboronic acid → 4-[5-(1,4-Diazatricyclo[4.3.1.13,8]undec-4-yl)pyridin-3-yl]benzonitrile

HRID 80444Notes

Reaction equation

HRID 80444 reaction equation
Br[C:2]1[CH:3]=[C:4]([N:8]2[CH2:16][CH:15]3[CH2:17][N:11]4[CH2:12][CH:13]([CH2:18][CH:9]2[CH2:10]4)[CH2:14]3)[CH:5]=[N:6][CH:7]=1.[C:19]([C:21]1[CH:26]=[CH:25][C:24](B(O)O)=[CH:23][CH:22]=1)#[N:20]>>[N:11]12[CH2:17][CH:15]3[CH2:14][CH:13]([CH2:18][CH:9]([N:8]([C:4]4[CH:3]=[C:2]([C:24]5[CH:25]=[CH:26][C:21]([C:19]#[N:20])=[CH:22][CH:23]=5)[CH:7]=[N:6][CH:5]=4)[CH2:16]3)[CH2:10]1)[CH2:12]2

Participants

3

Reactant 2

HCID 27343264-Cyanophenylboronic acidHCID 866492494-(5-Bromopyridin-3-yl)-1,4-diazatricyclo[4.3.1.13,8]undecane

Product 1

HCID 498694334-[5-(1,4-Diazatricyclo[4.3.1.13,8]undec-4-yl)pyridin-3-yl]benzonitrile

Procedure

The title compound was prepared from the product of Example 65A and 4-cyanophenylboronic acid according to General Method B: LC-MS Method D (ESI+) m/z 331.0 (M+H)+, retention time 1.26 minutes.

Sources & evidence

ORD record
ord-e2ee1a04e60e41e3a2256f1732a95ecf
Source dataset
uspto-grants-2014_09
Patent number
US08846661B2

Reaction notes

Loading…