4-Fluorophenylboronic acid → 4-[5-(4-Fluorophenyl)-1,3-thiazol-2-yl]-1,4-diazatricyclo[4.3.1.13,8]undecane

HRID 80461Notes

Reaction equation

HRID 80461 reaction equation
Br[C:2]1[S:6][C:5]([N:7]2[CH2:15][CH:14]3[CH2:16][N:10]4[CH2:11][CH:12]([CH2:17][CH:8]2[CH2:9]4)[CH2:13]3)=[N:4][CH:3]=1.[F:18][C:19]1[CH:24]=[CH:23][C:22](B(O)O)=[CH:21][CH:20]=1>>[F:18][C:19]1[CH:24]=[CH:23][C:22]([C:2]2[S:6][C:5]([N:7]3[CH2:15][CH:14]4[CH2:16][N:10]5[CH2:11][CH:12]([CH2:17][CH:8]3[CH2:9]5)[CH2:13]4)=[N:4][CH:3]=2)=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 2856454-Fluorophenylboronic acidHCID 866492624-(5-Bromo-1,3-thiazol-2-yl)-1,4-diazatricyclo[4.3.1.13,8]undecane

Product 1

HCID 498698584-[5-(4-Fluorophenyl)-1,3-thiazol-2-yl]-1,4-diazatricyclo[4.3.1.13,8]undecane

Procedure

The title compound was prepared from the product of Example 105A and 4-fluorophenylboronic acid according to General Method C: LC-MS Method D (ESI+) m/z 330.0 (M+H)+, retention time 1.51 minutes.

Sources & evidence

ORD record
ord-864b768f97b54c9ea8be6b9706aa3e24
Source dataset
uspto-grants-2014_09
Patent number
US08846661B2

Reaction notes

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