Ethyl 5-bromo-4-(3-chloro-4-fluorophenyl)-1,3-thiazole-2-carboxylate → 4-(3-Chloro-4-fluorophenyl)-5-(3-chlorophenyl)-1,3-thiazole-2-carboxylic acid
Reaction equation
[Br:25][c:26]1[s:27][c:28]([C:29]([O:30][CH2:31][CH3:32])=[O:33])[n:34][c:35]1-[c:36]1[cH:37][cH:38][c:39]([F:40])[c:41]([Cl:42])[cH:43]1.[Cl:1][c:2]1[cH:3][c:4](-[c:9]2[n:10][c:11]([C:22](=[O:23])[OH:24])[s:12][c:13]2-[c:14]2[cH:15][c:16]([Cl:21])[cH:17][c:18]([F:20])[cH:19]2)[cH:5][cH:6][c:7]1[F:8]>>[Cl:1][c:2]1[cH:3][c:4](-[c:9]2[n:10][c:11]([C:22](=[O:23])[OH:24])[s:12][c:13]2-[c:14]2[cH:15][c:16]([Cl:21])[cH:17][cH:18][cH:19]2)[cH:5][cH:6][c:7]1[F:8]Participants
3
Sources & evidence
- ORD record
- ord-65884dc0436142fa97b609754d8d0a42
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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