HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 8050Generated: October 25, 2026
Ethyl Acetate → 2-Nitro-5-(3-diethylamino-1-propoxy)aniline
https://huagongshe.com/reaction/8050
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Ammonium Carbonate | HCID 517111 | — |
| Reactant | 2-Fluoro-4-(3-diethylamino-1-propoxy)nitrobenzene | HCID 22014733 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-Nitro-5-(3-diethylamino-1-propoxy)aniline | HCID 22014718 | — |
Reaction Steps
The nitro compound obtained as above (1.5 mmol) is dissolved in DMF (4 mL) and added with ammonium carbonate (500 mg). The reaction mixture is then heated at 80° C. for 48 h. EtOAc (2×10 mL). The combined organic layers are then washed with water and brine and dried over Na2SO4. Removal of the solvent in vacuo yielded the 2-nitro-5-(3-diethylamino-1-propoxy)aniline (300 mg) which is used for further transformation without any purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07087632B2 |
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| Source dataset | uspto-grants-2006_08 |
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| ORD ID | ord-2376017b04d24493a40d98ac5b74b779 |
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| Source note | uspto-grants-2006_08 |
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