Hydrochloride methanol → cis-1,2,3,4,4a,5,6,11b-Octahydro-7h-pyrido[3,4-d][2]benzazepin-7-one

HRID 80524Notes

Reaction equation

HRID 80524 reaction equation
[O:1]=[C:2]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[C@H:6]2[CH2:13][CH2:14][N:15](C(OC(C)(C)C)=O)[CH2:16][C@H:5]2[CH2:4][NH:3]1.Cl.CO>C(OCC)C>[CH2:13]1[C@H:6]2[C@H:5]([CH2:4][NH:3][C:2](=[O:1])[C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=32)[CH2:16][NH:15][CH2:14]1

Participants

4

Reactant 2

HCID 21893726Hydrochloride methanolHCID 67249978Tert-butyl cis-7-oxo-1,2,4,4a,5,6,7,11b-octahydro-3h-pyrido[3,4-d][2]benzazepine-3-carboxylate

Product 1

HCID 49763200cis-1,2,3,4,4a,5,6,11b-Octahydro-7h-pyrido[3,4-d][2]benzazepin-7-one

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

To a suspension of Example 180G in 400 mL of diethyl ether was added 80 mL of HCl/methanol (5N) at 25° C. The mixture was stirred overnight. The solid formed was collected and dried to obtain the title compound as the hydrochloride salt.

Workup

  1. customThe solid formed
  2. customwas collected
  3. customdried

Sources & evidence

ORD record
ord-d2bdad8fad8543cd8a91346be6c25155
Source dataset
uspto-grants-2014_09
Patent number
US08846663B2

Reaction notes

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