HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(4-Methylpiperazine-1-carbonyl)phenylboronic acid pinacol ester → {4-[8-(2-Chloro-3,6-difluorobenzyl)-5,6,7,8-tetrahydropyrazino[2,3-b]pyrazin-2-yl]phenyl}(4-methylpiperazin-1-yl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(4-Methylpiperazine-1-carbonyl)phenylboronic acid pinacol ester | HCID 2760030 | — |
| Reactant | 7-Bromo-1-(2-chloro-3,6-difluorobenzyl)-1,2,3,4-tetrahydropyrazino[2,3-b]pyrazine | HCID 86659422 | — |
| Product | {4-[8-(2-Chloro-3,6-difluorobenzyl)-5,6,7,8-tetrahydropyrazino[2,3-b]pyrazin-2-yl]phenyl}(4-methylpiperazin-1-yl)methanone | HCID 67008447 | — |
Reaction Steps
The entitled compound was prepared from 7-bromo-1-(2-chloro-3,6-difluorobenzyl)-1,2,3,4-tetrahydropyrazino[2,3-b]pyrazine and 4-(4-Methylpiperazine-1-carbonyl)phenylboronic acid pinacol ester using Suzuki coupling conditions as described in Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08846664B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-008fb5da4340456da37fcbc2bcf7fefe |
| Source note | uspto-grants-2014_09 |