HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4-(3-Hydrazinyl-3-oxopropyl)phenyl)boronic acid → 3-{4-[8-(2-Chloro-3,6-difluorobenzyl)-5,6,7,8-tetrahydropyrazino[2,3-b]pyrazin-2-yl]phenyl}propanehydrazide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4-(3-Hydrazinyl-3-oxopropyl)phenyl)boronic acid | HCID 44118554 | — |
| Reactant | 7-Bromo-1-(2-chloro-3,6-difluorobenzyl)-1,2,3,4-tetrahydropyrazino[2,3-b]pyrazine | HCID 86659422 | — |
| Product | 3-{4-[8-(2-Chloro-3,6-difluorobenzyl)-5,6,7,8-tetrahydropyrazino[2,3-b]pyrazin-2-yl]phenyl}propanehydrazide | HCID 67007926 | — |
Reaction Steps
The entitled compound was prepared from 7-bromo-1-(2-chloro-3,6-difluorobenzyl)-1,2,3,4-tetrahydropyrazino[2,3-b]pyrazine and 4-(3-Hydrazino-3-oxopropyl)benzeneboronic acid using Suzuki coupling conditions as described in Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08846664B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-8e8fb2c241f5460fa05e1dd1b48f3589 |
| Source note | uspto-grants-2014_09 |