[3-(4-Methylpiperazine-1-carbonyl)phenyl]boronic acid → {3-[8-(2-Chloro-3,6-difluorobenzyl)-5,6,7,8-tetrahydropyrazino[2,3-b]pyrazin-2-yl]phenyl}(4-methylpiperazin-1-yl)methanone

Participants

Reaction Steps

The entitled compound was prepared from 7-bromo-1-(2-chloro-3,6-difluorobenzyl)-1,2,3,4-tetrahydropyrazino[2,3-b]pyrazine and 3-(4-Methylpiperazine-1-carbonyl)phenylboronicacid, pinacol ester using Suzuki coupling conditions as described in Example 1.

Provenance & Evidence