化工社化工社 化学情報印刷レポート · 研究参考用
1-Methyl-4-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)piperazine → 1-(2-Chloro-3,6-difluorobenzyl)-7-[2-(4-methylpiperazin-1-yl)pyridine-4-yl]-1,2,3,4-tetrahydropyrazino[2,3-b]pyrazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Methyl-4-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)piperazine | HCID 2769618 | — |
| 反応物 | 7-Bromo-1-(2-chloro-3,6-difluorobenzyl)-1,2,3,4-tetrahydropyrazino[2,3-b]pyrazine | HCID 86659422 | — |
| 生成物 | 1-(2-Chloro-3,6-difluorobenzyl)-7-[2-(4-methylpiperazin-1-yl)pyridine-4-yl]-1,2,3,4-tetrahydropyrazino[2,3-b]pyrazine | HCID 67008120 | — |
反応手順
The entitled compound was prepared from 7-bromo-1-(2-chloro-3,6-difluorobenzyl)-1,2,3,4-tetrahydropyrazino[2,3-b]pyrazine and 2-(4-Methylpiperazin-1-yl)pyridine-5-boronic acid pinacol ester using Suzuki coupling conditions as described in Scheme 1.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08846664B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-1b2a570010d3433b8823c2b585dad185 |
| 出典メモ | uspto-grants-2014_09 |